Spurs were beaten 1-0 by Belgian side Royal Antwerp on Thursday night, as Jose Mourinho’ second string missed out on a chance to impress.
In the Premier League however, Spurs have been in excellent form, with Monday night’s win over Burnley taking them within a point of the top four.
Brighton, meanwhile, have struggled to turn decent performances into good results and have not won since beating Newcastle on September 20.
Tottenham head coach Jose Mourinho is set to rotate his squad after describing Spurs’ performance in the midweek Europa League defeat as poor.
Eric Dier and Tanguy Ndombele are expected to be fit after being rested for Thursday’s game as a precaution.
Brighton captain Lewis Dunk is banned and forward Alireza Jahanbakhsh is out with a hamstring problem.
Midfielder Davy Propper has a slim chance of featuring after returning from an Achilles injury.
Danny Welbeck could make his first appearance for the club. He was an unused substitute for Monday’s draw with West Brom.
- Tottenham have won their past five home meetings with Brighton in all competitions.
- Brighton have lost six successive away matches against Spurs.
- The Seagulls haven’t won at Tottenham since a 1-0 victory in October 1981.
- Tottenham are unbeaten in five league matches (W3, D2).
- They have scored a league-high 16 goals going into this weekend.
- However, they could go four home league fixtures without a win for the first time since December 2013.
- Harry Kane has been directly involved in 13 goals this season, the most ever recorded by a player after six games of a Premier League campaign.
- Kane’s eight assists in six Premier League appearances is already the most he has provided in an entire season.
- Son Heung-min has scored 10 goals in his past seven games in all competitions, with eight of those coming in the Premier League.
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Brighton & Hove Albion
- Brighton have drawn their past two matches and have won just once in the league this season (D2, L3).
- Nonetheless, the Seagulls have lost just one of their past 10 Premier League away games (W3, D6).
- Albion have conceded seven goals from set-pieces in the Premier League this season, the highest number in the division.
- They have lost 16 of their past 18 Premier League away fixtures versus the established top-six teams (W1, D1).
- Neal Maupay has scored four of Brighton’s five first-half goals in this season’s Premier League – the other was an own goal.