Arsenal will be looking to continue their near excellent start to the season with a trip to Manchester City.
The Gunners have won three out of four in the EPL losing only to champions Liverpool, while also winning the Community Shield and reaching the quarter-finals of the Carabao Cup.
However, Mikel Arteta’s side now face a testing run, with the start of their Europa League campaign sandwiched between league games against City, Leicester and Manchester United.
City, meanwhile, will be hoping to bounce back to winning ways following a 1-1 draw with Leeds and a 5-2 thumping at the hands of Leicester prior to the international break.
Mikel Arteta got the better of his old master in last season’s FA Cup semi-final and will surely employ a similar approach, but Tierney will be a huge miss, both for his defensive solidity and the balance he brings going forward.
City can ill-afford to lose further early ground in the title race.
Manchester City’s Kevin De Bruyne will miss Saturday’s game because of the unspecified injury he sustained on international duty this week.
Raheem Sterling is fit, while Sergio Aguero might feature for the first time since requiring knee surgery in June.